Analysis of Influencing Factors of Repair Effect after Peripheral Nerve Injury

Comput Math Methods Med. 2021 Nov 23:2021:8294267. doi: 10.1155/2021/8294267. eCollection 2021.

Abstract

In order to improve the repair effect after peripheral nerve injury, this paper analyzes the related influencing factors. The regeneration of peripheral nerve includes two continuous and overlapping processes: the acute wound healing period and the axon seeking target tissue period. The complete and effective process of peripheral nerve regeneration includes the sprouting, growth and extension of regenerated axons, and the reconstruction of synaptic connections (neuromuscular junctions) with target organs to realize the reinnervation of nerves and restore function. This process includes three indicators of success in regeneration: structural reconstruction, metabolic regeneration, and functional recovery. In order to improve the repair effect of peripheral nerve injury, relevant influencing factors can be analyzed, and effective improvement of these influencing factors can improve the recovery effect of peripheral nerve injury. Finally, this paper analyzes multiple factors to provide theoretical references for follow-up clinical diagnosis and treatment.

Publication types

  • Retracted Publication

MeSH terms

  • Animals
  • Axons / physiology
  • Computational Biology
  • Disease Models, Animal
  • Female
  • Humans
  • Male
  • Models, Neurological
  • Nerve Growth Factors / physiology
  • Nerve Regeneration / physiology*
  • Peripheral Nerve Injuries / physiopathology*
  • Peripheral Nerve Injuries / therapy*
  • Recovery of Function / physiology
  • Schwann Cells / physiology

Substances

  • Nerve Growth Factors