Herein, we report a one-pot, three-component method for the preparation of 3-substituted pyridines and carbolines via copper-free, palladium-catalyzed Sonogashira cross-coupling with aryl iodides, followed by 6π-aza cyclization. This arylation cross-coupling/annulation cascade provides easy access to substituted, fused pyridines from readily available substrates in good yields (67-92%) with complete selectivity.