Mammographic texture features associated with contralateral breast cancer in the WECARE Study

Gordon P Watt; Julia A Knight; Christine Lin; Charles F Lynch; Kathleen E Malone; Esther M John; Leslie Bernstein; Jennifer D Brooks; Anne S Reiner; Xiaolin Liang; Meghan Woods; Tuong L Nguyen; John L Hopper; Malcolm C Pike; Jonine L Bernstein

doi:10.1038/s41523-021-00354-1

Mammographic texture features associated with contralateral breast cancer in the WECARE Study

NPJ Breast Cancer. 2021 Nov 29;7(1):146. doi: 10.1038/s41523-021-00354-1.

Authors

Gordon P Watt¹, Julia A Knight^{2

3}, Christine Lin⁴, Charles F Lynch⁵, Kathleen E Malone⁶, Esther M John^{7

8}, Leslie Bernstein⁹, Jennifer D Brooks³, Anne S Reiner¹⁰, Xiaolin Liang¹⁰, Meghan Woods¹⁰, Tuong L Nguyen¹¹, John L Hopper¹¹, Malcolm C Pike¹⁰, Jonine L Bernstein¹⁰

Affiliations

¹ Memorial Sloan Kettering Cancer Center, New York, NY, USA. wattg@mskcc.org.
² Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, ON, Canada.
³ Division of Epidemiology, Dalla Lana School of Public Health, Toronto, ON, Canada.
⁴ Penn State College of Medicine, Hershey, PA, USA.
⁵ Department of Epidemiology, University of Iowa, Iowa City, IA, USA.
⁶ Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
⁷ Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, USA.
⁸ Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
⁹ Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA.
¹⁰ Memorial Sloan Kettering Cancer Center, New York, NY, USA.
¹¹ Melbourne School of Population and Global Health, University of Melbourne, Parkville, VIC, Australia.

Abstract

To evaluate whether mammographic texture features were associated with second primary contralateral breast cancer (CBC) risk, we created a "texture risk score" using pre-treatment mammograms in a case-control study of 212 women with CBC and 223 controls with unilateral breast cancer. The texture risk score was associated with CBC (odds per adjusted standard deviation = 1.25, 95% CI 1.01-1.56) after adjustment for mammographic percent density and confounders. These results support the potential of texture features for CBC risk assessment of breast cancer survivors.

Abstract

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