Advance research in biomedical applications on marine sulfated polysaccharide

Int J Biol Macromol. 2022 Jan 1:194:870-881. doi: 10.1016/j.ijbiomac.2021.11.142. Epub 2021 Nov 27.

Abstract

Marine ecosystem associated organisms are an affluent source of bioactive compounds. Polysaccharides with unique structural and practical entities have gained special studies interest inside the current biomedical zone. Polysaccharides are the main components of marine algae, plants, animals, insects, and microorganisms. In recent times research on seaweed is more persistent for extraction of natural bioactive "Sulfated polysaccharides" (SPs). The considerable amount of SP exists in the algae in the form of fucans, fucoidans, carrageenans, ulvan, etc. Major function of SPs is to act as a defensive lattice towards the infective organism. All SPs possess the high potential and possess a broad range of therapeutic applications as antitumor, immunomodulatory, vaccine adjuvant, anti-inflammatory, anticoagulant, antiviral, antiprotozoal, antimicrobial, antilipemic, therapy of regenerative medicine, also in drug delivery and tissue engineering application. This review aims to discuss the biomedicine applications of sulfated polysaccharides from marine seaweeds.

Keywords: Antitumor; Immunomodulatory; Nontoxicity emphasize; Seaweed; Sulfated polysaccharide; Vaccine adjuvant.

Publication types

  • Review

MeSH terms

  • Aquatic Organisms / chemistry*
  • Biocompatible Materials / chemistry
  • Biomedical Research*
  • Chemical Phenomena
  • Dietary Carbohydrates
  • Drug Delivery Systems
  • Drug Development
  • Molecular Structure
  • Plants / chemistry
  • Polysaccharides / chemistry*
  • Polysaccharides / pharmacology
  • Seaweed / chemistry
  • Sulfates / chemistry*
  • Tissue Engineering

Substances

  • Biocompatible Materials
  • Dietary Carbohydrates
  • Polysaccharides
  • Sulfates