West Nile virus (WNV) is the most common domestic arbovirus in the United States. During 2018, WNV was transmitted through solid organ transplantation to 2 recipients who had neuroinvasive disease develop. Because of increased illness and death in transplant recipients, organ procurement organizations should consider screening during region-specific WNV transmission months.
Keywords: United States; West Nile virus; arboviruses; donor screening; neuroinvasive disease; organ donor screening practices; organ procurement organization; solid organ transplantation; transmission; viruses.