Two-Photon Polymerization of Albumin Hydrogel Nanowires Strengthened with Graphene Oxide

Biomimetics (Basel). 2021 Nov 24;6(4):66. doi: 10.3390/biomimetics6040066.

Abstract

Multifunctional biomaterials can pave a way to novel types of micro- and nanoelectromechanical systems providing benefits in mimicking of biological functions in implantable, wearable structures. The production of biocomposites that hold both superior electrical and mechanical properties is still a challenging task. In this study, we aim to fabricate 3D printed hydrogel from a biocomposite of bovine serum albumin with graphene oxide (BSA@GO) using femtosecond laser processing. We have developed the method for functional BSA@GO composite nanostructuring based on both two-photon polymerization of nanofilaments and direct laser writing. The atomic-force microscopy was used to probe local electrical and mechanical properties of hydrogel BSA@GO nanowires. The improved local mechanical properties demonstrate synergistic effect in interaction of femtosecond laser pulses and novel composite structure.

Keywords: bovine serum albumin; electrical properties; filament propagation; graphene oxide; mechanical properties; nanowires; two-photon polymerization.