The effect of almond intake on glycemic control: A systematic review and dose-response meta-analysis of randomized controlled trials

Omid Asbaghi; Vihan Moodi; Azadeh Neisi; Mina Shirinbakhshmasoleh; Sajjad Abedi; Fatemeh Hosseini Oskouie; Elham Eslampour; Ehsan Ghaedi; Maryam Miraghajani

doi:10.1002/ptr.7328

The effect of almond intake on glycemic control: A systematic review and dose-response meta-analysis of randomized controlled trials

Phytother Res. 2022 Jan;36(1):395-414. doi: 10.1002/ptr.7328. Epub 2021 Nov 29.

Authors

Omid Asbaghi¹, Vihan Moodi², Azadeh Neisi³, Mina Shirinbakhshmasoleh⁴, Sajjad Abedi⁴, Fatemeh Hosseini Oskouie⁵, Elham Eslampour⁶, Ehsan Ghaedi⁷, Maryam Miraghajani^{1

8}

Affiliations

¹ Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
² School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
³ Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.
⁴ Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
⁵ Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁶ Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.
⁷ Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
⁸ The Early Life Research Unit, Academic Division of Child Health, Obstetrics and Gynaecology, and Nottingham Digestive Disease Centre and Biomedical Research Centre, The School of Medicine, University of Nottingham, Nottingham, UK.

PMID: 34841609
DOI: 10.1002/ptr.7328

Abstract

Number trials have evaluated the effect of almond intake on glycemic control in adults; however, the results remain equivocal. Therefore, the present meta-analysis aims to examine the effectiveness of almond intake on glycemic parameters. Online databases including PubMed, Scopus, ISI web of science, Embase, and Cochrane Library were searched up to August 2021 for trials that examined the effect of almond intake on glycemic control parameters including fasting blood sugar (FBS), insulin, HOMA-IR, and HbA1C. Treatment effects were expressed as mean difference (MD) and the standard deviation (SD) of outcomes. To estimate the overall effect of almond intake, we used the random-effects model. In total, 24 studies with 31 arms were included in our analysis. The meta-analysis revealed that almond intake did not significantly change the concentrations of FBS, HbA1c, insulin levels, and HOMA-IR. In conclusion, there is currently no convincing evidence that almonds have a clear beneficial effect on glycemic control. Future studies are needed before any confirmed conclusion could be drowned.

Keywords: almond; glycemic control; meta-analysis; nuts; systematic review.

Publication types

Meta-Analysis
Review
Systematic Review

MeSH terms

Blood Glucose
Humans
Insulin
Insulin Resistance*
Prunus dulcis*
Randomized Controlled Trials as Topic

Substances

Blood Glucose
Insulin