EEG-based visual deviance detection in freely behaving mice

Renate Kat; Berry van den Berg; Matthijs Jl Perenboom; Maarten Schenke; Arn Mjm van den Maagdenberg; Hilgo Bruining; Else A Tolner; Martien Jh Kas

doi:10.1016/j.neuroimage.2021.118757

EEG-based visual deviance detection in freely behaving mice

Neuroimage. 2021 Dec 15:245:118757. doi: 10.1016/j.neuroimage.2021.118757. Epub 2021 Nov 24.

Authors

Renate Kat¹, Berry van den Berg², Matthijs Jl Perenboom³, Maarten Schenke⁴, Arn Mjm van den Maagdenberg⁵, Hilgo Bruining⁶, Else A Tolner⁷, Martien Jh Kas⁸

Affiliations

¹ Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen, Nijenborgh 7, 9747 AG, Groningen, the Netherlands. Electronic address: r.kat@rug.nl.
² Faculty of Behavioral and Social Sciences, Cognitive Neuroscience, Department of Experimental Psychology, University of Groningen, Grote Kruisstraat 2/1, 9712 TS, Groningen, the Netherlands. Electronic address: berry.van.den.berg@rug.nl.
³ Department of Neurology, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, the Netherlands. Electronic address: M.J.L.Perenboom@lumc.nl.
⁴ Department of Human Genetics, Leiden University Medical Center, Einthovenweg 20, 2300 RC, Leiden, the Netherlands.
⁵ Department of Neurology, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, the Netherlands; Department of Human Genetics, Leiden University Medical Center, Einthovenweg 20, 2300 RC, Leiden, the Netherlands. Electronic address: A.M.J.M.van_den_Maagdenberg@lumc.nl.
⁶ Department of Child and Adolescent Psychiatry, Amsterdam University Medical Center, University of Amsterdam, Postbus 7057, 1007 MB, Amsterdam, the Netherlands. Electronic address: h.bruining@amsterdamumc.nl.
⁷ Department of Neurology, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, the Netherlands; Department of Human Genetics, Leiden University Medical Center, Einthovenweg 20, 2300 RC, Leiden, the Netherlands. Electronic address: E.A.Tolner@lumc.nl.
⁸ Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen, Nijenborgh 7, 9747 AG, Groningen, the Netherlands. Electronic address: m.j.h.kas@rug.nl.

PMID: 34838751
DOI: 10.1016/j.neuroimage.2021.118757

Abstract

The mouse is widely used as an experimental model to study visual processing. To probe how the visual system detects changes in the environment, functional paradigms in freely behaving mice are strongly needed. We developed and validated the first EEG-based method to investigate visual deviance detection in freely behaving mice. Mice with EEG implants were exposed to a visual deviant detection paradigm that involved changes in light intensity as standard and deviant stimuli. By subtracting the standard from the deviant evoked waveform, deviant detection was evident as bi-phasic negativity (starting around 70 ms) in the difference waveform. Additionally, deviance-associated evoked (beta/gamma) and induced (gamma) oscillatory responses were found. We showed that the results were stimulus-independent by applying a "flip-flop" design and the results showed good repeatability in an independent measurement. Together, we put forward a validated, easy-to-use paradigm to measure visual deviance processing in freely behaving mice.

Keywords: Mismatch negativity; Sensory processing deficits; Visual processing.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Electroencephalography*
Male
Mice
Mice, Inbred C57BL
Photic Stimulation
Reproducibility of Results
Visual Perception / physiology*