The Batman and Robin of liver-stage immunity to malaria

William R Heath; Lauren E Holz; Daniel Fernandez-Ruiz

doi:10.1016/j.pt.2021.11.002

The Batman and Robin of liver-stage immunity to malaria

Trends Parasitol. 2022 Jan;38(1):7-8. doi: 10.1016/j.pt.2021.11.002. Epub 2021 Nov 24.

Authors

William R Heath¹, Lauren E Holz², Daniel Fernandez-Ruiz²

Affiliations

¹ Department of Microbiology and Immunology, The Doherty Institute for Infection and Immunity, The University of Melbourne, Victoria, 3010, Australia. Electronic address: wrheath@unimelb.edu.au.
² Department of Microbiology and Immunology, The Doherty Institute for Infection and Immunity, The University of Melbourne, Victoria, 3010, Australia.

PMID: 34836817
DOI: 10.1016/j.pt.2021.11.002

Abstract

Malaria parasites replicate within the liver shortly after infection. This stage can be controlled by CD8 T cells, but which subsets undertake this function is unclear. Lefebvre et al. now elegantly show that effector memory T (T_EM) cells are avid participants, working as a dynamic duo with liver tissue-resident memory T (T_RM) cells to combat infection.

Keywords: CD8 T cells; liver; malaria; memory; vaccines.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
CD8-Positive T-Lymphocytes / immunology
Humans
Immunologic Memory / immunology
Liver / parasitology
Malaria* / parasitology
Songbirds*