Potential inhibitors of microglial activation from the roots of Vernicia montana Lour

Yingjie Wang; Gang Chen; Qingqi Meng; Xiaohu Yao; Yang Li; Honglin Cao; Bin Lin; Yue Hou; Di Zhou; Ning Li

doi:10.1016/j.phytochem.2021.113019

Potential inhibitors of microglial activation from the roots of Vernicia montana Lour

Phytochemistry. 2022 Feb:194:113019. doi: 10.1016/j.phytochem.2021.113019. Epub 2021 Nov 23.

Authors

Yingjie Wang¹, Gang Chen², Qingqi Meng³, Xiaohu Yao³, Yang Li¹, Honglin Cao⁴, Bin Lin⁵, Yue Hou³, Di Zhou⁶, Ning Li⁷

Affiliations

¹ School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China.
² School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, China; Sate Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, China.
³ College of Life and Health Sciences, Northeastern University, Shenyang, 110004, China.
⁴ South China Botanical Garden, Chinese Academy of Sciences, Guanzhou, 510650, China.
⁵ School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, China.
⁶ School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China. Electronic address: zhoudi930322@163.com.
⁷ School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China. Electronic address: liningsypharm@163.com.

PMID: 34826794
DOI: 10.1016/j.phytochem.2021.113019

Abstract

During our continuous investigation of natural, herbal inhibitors of microglial over-activation in the Euphorbiaceae family, two plants of the Vernicia genus showed remarkable inhibitory effects on nitric oxide (NO) production in over-activated microglia. In this study, bioactivity-guided phytochemical research on the active fraction of the roots of V. montana was carried out. As a result, seven undescribed terpenoids and lignans, together with thirty-one known components, were isolated and identified using comprehensive spectral analysis. All the identified compounds were evaluated for their inhibitory effects on NO production in lipopolysaccharide-stimulated BV-2 cells. Combined with our previous research on the Vernicia genus, the effective material basis of different plants and medicinal components was analyzed systematically.

Keywords: Euphorbiaceae; Lignans; Microglia; Terpenoids; Vernicia montana Lour..

MeSH terms

Euphorbiaceae*
Microglia*
Montana