Improved water dispersion and bioavailability of coenzyme Q10 by bacterial cellulose nanofibers

Yuanyuan Li; Qilei Yang; Bingxue Liu; Qian Zhang; Yanjie Liu; Xiuhua Zhao; Shujun Li

doi:10.1016/j.carbpol.2021.118788

Improved water dispersion and bioavailability of coenzyme Q10 by bacterial cellulose nanofibers

Carbohydr Polym. 2022 Jan 15:276:118788. doi: 10.1016/j.carbpol.2021.118788. Epub 2021 Oct 21.

Authors

Yuanyuan Li¹, Qilei Yang², Bingxue Liu², Qian Zhang², Yanjie Liu², Xiuhua Zhao³, Shujun Li⁴

Affiliations

¹ College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, China, Harbin 150040, Heilongjiang, China; Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, Heilongjiang, China; Key Laboratory of Bio-Based Material Science and Technology of Ministry of Education Northeast Forestry University, Harbin 150040, Heilongjiang, China.
² College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, China, Harbin 150040, Heilongjiang, China; Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, Heilongjiang, China.
³ College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, China, Harbin 150040, Heilongjiang, China; Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, Heilongjiang, China. Electronic address: xiuhuazhao@nefu.edu.cn.
⁴ Key Laboratory of Bio-Based Material Science and Technology of Ministry of Education Northeast Forestry University, Harbin 150040, Heilongjiang, China. Electronic address: lishujun@nefu.edu.cn.

PMID: 34823798
DOI: 10.1016/j.carbpol.2021.118788

Abstract

The purpose of this study was to investigate the potential of bacterial cellulose nanofiber suspension (BCNs) as stabilizer in anti-solvent precipitation and its effect on improving bioavailability of coenzyme Q10. Bacterial cellulose (BC) was hydrolyzed by sulfuric acid followed by the oxidation with hydrogen peroxide to prepare BCNs. The suspension of BCNs-loaded CoQ10 (CoQ10-BCNs) were prepared by antisolvent precipitation. The zeta potential of CoQ10-BCNs was about -36.01 mV. The properties of CoQ10, BCNs and CoQ10-BCNs were studied by scanning electron microscopy, transmission electron microscope, Fourier-transform infrared spectroscopy, X-ray diffraction, differential scanning calorimetry and thermo gravimetric analysis. The crystallinity of CoQ10 decreased in CoQ10-BCNs compared with the raw CoQ10, and CoQ10-BCNs have good physicochemical stability. In oral bioavailability studies, the area under curve (AUC) of CoQ10-BCNs was about 3.62 times higher than the raw CoQ10 in rats.

Keywords: Antisolvent precipitation; Bacterial cellulose; Bioavailability; Coenzyme Q10; Nanosuspensions.

MeSH terms

Administration, Oral
Animals
Biological Availability
Calorimetry, Differential Scanning / methods
Cellulose / chemistry*
Gluconacetobacter xylinus / metabolism
Microscopy, Electron, Scanning / methods
Nanofibers / chemistry*
Polysaccharides, Bacterial / chemistry*
Rats
Rats, Sprague-Dawley
Solubility
Solvents / chemistry
Spectroscopy, Fourier Transform Infrared / methods
Suspensions
Thermogravimetry / methods
Ubiquinone / analogs & derivatives*
Ubiquinone / chemistry
Ubiquinone / pharmacokinetics
Water / chemistry*
X-Ray Diffraction / methods

Substances

Polysaccharides, Bacterial
Solvents
Suspensions
Water
Ubiquinone
Cellulose
coenzyme Q10