The importance of including African populations in pharmacogenetics studies of warfarin response

Collet Dandara; Arinao Ndadza; Nyarai Soko

doi:10.2217/pgs-2021-0142

The importance of including African populations in pharmacogenetics studies of warfarin response

Pharmacogenomics. 2022 Jan;23(1):1-4. doi: 10.2217/pgs-2021-0142. Epub 2021 Nov 25.

Authors

Collet Dandara¹, Arinao Ndadza¹, Nyarai Soko¹

Affiliation

¹ Department of Pathology & Institute of Infectious Diseases & Molecular Medicine, Pharmacogenomics & Drug Metabolism Research Group, Division of Human Genetics, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa.

PMID: 34821506
DOI: 10.2217/pgs-2021-0142

Abstract

Tweetable abstract Warfarin will remain in use for a long time to come, thus inclusion of African populations in pharmacogenomics is essential to be able to identify all possible biomarkers that are potential predictors for warfarin drug response.

Keywords: Africa; pharmacogenomics; warfarin.

Plain language summary

Tweetable abstract Warfarin will remain in use for a long time to come, thus inclusion of African populations in pharmacogenomics is essential to be able to identify all possible biomarkers that are potential predictors for warfarin drug response.

Publication types

Editorial
Research Support, Non-U.S. Gov't

MeSH terms

Africa
Anticoagulants / pharmacology*
Cytochrome P-450 CYP2C9 / genetics
Humans
Pharmacogenetics*
Polymorphism, Single Nucleotide
Vitamin K Epoxide Reductases / genetics
Warfarin / pharmacology*

Substances

Anticoagulants
Warfarin
Cytochrome P-450 CYP2C9
VKORC1 protein, human
Vitamin K Epoxide Reductases