Exposure to multiple mycotoxins in domestic and imported rice commercially traded in Tehran and possible risk to public health

Samira Eslamizad; Hassan Yazdanpanah; Zahra Hadian; Christina Tsitsimpikou; Marina Goumenou; Mohammad Hossein Shojaee AliAbadi; Mahdie Kamalabadi; Aristides Tsatsakis

doi:10.1016/j.toxrep.2021.11.008

Exposure to multiple mycotoxins in domestic and imported rice commercially traded in Tehran and possible risk to public health

Toxicol Rep. 2021 Nov 5:8:1856-1864. doi: 10.1016/j.toxrep.2021.11.008. eCollection 2021.

Authors

Samira Eslamizad¹, Hassan Yazdanpanah^{1

2}, Zahra Hadian³, Christina Tsitsimpikou⁴, Marina Goumenou⁵, Mohammad Hossein Shojaee AliAbadi⁶, Mahdie Kamalabadi⁷, Aristides Tsatsakis⁵

Affiliations

¹ Food Safety Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
² Department of Toxicology and Pharmacology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
³ Department of Food Technology Research, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Farahzadi Blv. West Hafezi, No 7. P. O. Box 19395-4741, Tehran, Islamic Republic of Iran.
⁴ General Chemical State Laboratory of Greece, 11521, Athens, Greece.
⁵ Center of Toxicology Science & Research, Medical School, University of Crete, Heraklion, Crete, Greece.
⁶ Faroogh Life Sciences Research Laboratory, Tehran, Islamic Republic of Iran.
⁷ Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Islamic Republic of Iran.

Abstract

Mycotoxins are secondary fungi metabolites that induce acute and chronic toxic effects in humans and animals. In the present study, nine mycotoxins including aflatoxins (AFB₁, AFB₂, AFG₁ and AFG₂), fumonisins (FB₁ and FB₂), Ochratoxin A (OTA), deoxynivalenol (DON), and zearalenone (ZEN) were determined in one hundred rice samples collected from Tehran using high performance liquid chromatography (HPLC) with fluorescence or photodiode array detector. In addition, possible risk to public health was investigated by assessing dietary exposure through rice consumption, the margin of exposure (MOE), respective risk of cancer and hazard index (HI) of the monitored mycotoxins in children and adults. The higher mean levels were determined for DON (102.22 μg.Kg^-1), followed by FB₁ (85.00 μg.Kg^-1). For the rests of mycotoxins the levels did not exceed 20 μg.Kg^-1. The estimated AFB₁ intake for the adults and children through rice consumption exceeds the safe levels established for both carriers and non-carriers of hepatitis B virus. The mean and median determined exposure levels of OTA, DON ZEN and FB₁, were found lower than the Provisional Maximum Tolerable Daily Intake (PMTDI) value for both adults and children of Tehran that consuming domestic and imported rice. The mean HI for adults and median HI for adults and children were below one, and mean HI for children was close to one. All the mean, median and maximum MoE values were <10,000 in adults and children, indicating a risk due to AFB₁ exposure through rice consumption in Tehran. In addition, the calculated mean cancer risk in adult and child populations of Tehran were 0.27 and 0.64 cases per year per 10⁵ individuals, respectively, that shows population in Tehran could be at risk of cancer due to AFB₁ exposure through rice consumption as calculated. So further studies are necessary for the monitoring mycotoxins in rice and different food products as well as estimating average dietary exposure and cumulative exposure assessment of mycotoxins for main foods in IR Iran.

Keywords: Aflatoxin; Deoxynivalenol; Fumonisin; Ochratoxin A; Risk assessment; Zearalenone.