Recent Research Progress (2015-2021) and Perspectives on the Pharmacological Effects and Mechanisms of Tanshinone IIA

Chenhui Zhong; Zuan Lin; Liyuan Ke; Peiying Shi; Shaoguang Li; Liying Huang; Xinhua Lin; Hong Yao

doi:10.3389/fphar.2021.778847

Recent Research Progress (2015-2021) and Perspectives on the Pharmacological Effects and Mechanisms of Tanshinone IIA

Front Pharmacol. 2021 Nov 8:12:778847. doi: 10.3389/fphar.2021.778847. eCollection 2021.

Authors

Chenhui Zhong¹, Zuan Lin¹, Liyuan Ke¹, Peiying Shi², Shaoguang Li¹, Liying Huang¹, Xinhua Lin^{1

3}, Hong Yao^{1

3

4}

Affiliations

¹ Department of Pharmaceutical Analysis, School of Pharmacy, Fujian Medical University, Fuzhou, China.
² Department of Traditional Chinese Medicine Resource and Bee Products, College of Animal Sciences (College of Bee Science), Fujian Agriculture and Forestry University, Fuzhou, China.
³ Higher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, Fujian Medical University, Fuzhou, China.
⁴ Fujian Key Laboratory of Drug Target Discovery and Structural and Functional Research, Fujian Medical University, Fuzhou, China.

Abstract

Tanshinone IIA (Tan IIA) is an important characteristic component and active ingredient in Salvia miltiorrhiza, and its various aspects of research are constantly being updated to explore its potential application. In this paper, we review the recent progress on pharmacological activities and the therapeutic mechanisms of Tan IIA according to literature during the years 2015-2021. Tan IIA shows multiple pharmacological effects, including anticarcinogenic, cardiovascular, nervous, respiratory, urinary, digestive, and motor systems activities. Tan IIA modulates multi-targets referring to Nrf2, AMPK, GSK-3β, EGFR, CD36, HO-1, NOX4, Beclin-1, TLR4, TNF-α, STAT3, Caspase-3, and bcl-2 proteins and multi-pathways including NF-κB, SIRT1/PGC1α, MAPK, SREBP-2/Pcsk9, Wnt, PI3K/Akt/mTOR pathways, TGF-β/Smad and Hippo/YAP pathways, etc., which directly or indirectly influence disease course. Further, with the reported targets, the potential effects and possible mechanisms of Tan IIA against diseases were predicted by bioinformatic analysis. This paper provides new insights into the therapeutic effects and mechanisms of Tan IIA against diseases.

Keywords: bioinformatic analysis; molecular mechanism; pharmacokinetics; pharmacological effects; tanshinone IIA.

Publication types

Review