Plantar fascial fibromatosis and herpes zoster

Chao-Yu Hsu; Der-Shin Ke; Cheng-Li Lin; Chia-Hung Kao

doi:10.1371/journal.pone.0259942

Plantar fascial fibromatosis and herpes zoster

PLoS One. 2021 Nov 24;16(11):e0259942. doi: 10.1371/journal.pone.0259942. eCollection 2021.

Authors

Chao-Yu Hsu^{1

2

3

4

5}, Der-Shin Ke¹, Cheng-Li Lin^{6

7}, Chia-Hung Kao^{8

9

10

11}

Affiliations

¹ Department of Medical Education, Ditmanson Medical Foundation, Chia-Yi Christian Hospital, Chia-Yi, Taiwan.
² Department of Optometry/Medical Imaging and Radiological Sciences, Central Taiwan University of Science and Technology, Taichung, Taiwan.
³ Center for General Education, National Taichung University of Science and Technology, Taichung, Taiwan.
⁴ Department of General Education, National Chin-Yi University of Technology, Taichung, Taiwan.
⁵ Rural Generalist Program Japan, GENEPRO, Asahi Shi, Japan.
⁶ Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan.
⁷ College of Medicine, China Medical University, Taichung, Taiwan.
⁸ Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung, Taiwan.
⁹ Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan.
¹⁰ Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan.
¹¹ Center of Augmented Intelligence in Healthcare, China Medical University Hospital, Taichung, Taiwan.

Abstract

Purpose: Infection, chronic pain and depression are considered risk factors for herpes zoster (HZ). However, the correlation between plantar fascial fibromatosis (PFF) and HZ remains unknown. This study investigated HZ risk in patients with PFF.

Methods: Data was extracted from the Longitudinal Health Insurance Database 2000, which is a subsample of the Taiwan National Health Insurance (NHI) Research Database and contains 1 million NHI beneficiaries. Between 2000 and 2012, patients diagnosed as having PFF were included in the case cohort. Every case was age and sex-matched with individuals without PFF through 1:4 frequency matching (control cohort). The end of the follow-up was defined as December 31, 2013, the date of HZ diagnosis, death, emigration, or withdrawal from the NHI program.

Results: In total, 4,729 patients were diagnosed as having PFF and were matched with 18,916 individuals without PFF. Patients with PFF were 1.23 times more likely to develop HZ than were those without PFF. Among those aged ≥65 years, patients with PFF had a higher HZ risk than did those without PFF (adjusted hazard ratio [aHR] = 1.48). Men with PFF had a significantly higher risk of HZ than did men without PFF (aHR = 1.44).

Conclusion: Patients with PFF, particularly older and male patients, having a high HZ risk and may thus be vaccinated for HZ.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Chronic Pain
Databases, Factual
Fasciitis, Plantar
Female
Fibromatosis, Plantar / epidemiology*
Fibromatosis, Plantar / virology*
Herpes Zoster / epidemiology
Herpes Zoster / etiology*
Humans
Insurance, Health
Male
Middle Aged
Persistent Infection
Risk Factors
Taiwan

Grants and funding

This study is supported in part by Taiwan Ministry of Health and Welfare Clinical Trial Center in the form of funds to CHK [MOHW110-TDU-B-212-124004] and the China Medical University Hospital [DMR-109-231, DMR-110-089]. The funders had no role in the study design, data collection and analysis, the decision to publish, or preparation of the manuscript. No additional external funding was received for this study.