Tumor glycolytic heterogeneity improves detection of regional nodal metastasis in patients with lung adenocarcinoma

Abstract

Objective: The diagnostic performance of ¹⁸F-FDG PET for detecting regional lymph node metastasis in resectable lung cancer is variable, and its sensitivity for adenocarcinoma is even lower. We aimed to evaluate the value of ¹⁸F-FDG PET-derived features in predicting pathological lymph node metastasis in patients with lung adenocarcinoma.

Methods: We retrospectively analyzed pretreatment ¹⁸F-FDG PET-derived features of 126 lung adenocarcinoma patients who underwent curative surgery. A logistic regression model was used to analyze the association between study variables and pathological regional lymph node status obtained from the curative surgery. Furthermore, Cox regression analysis was used to test the effect of the study variables on survival outcomes, including disease-free survival (DFS) and overall survival (OS).

Results: The primary tumor entropy (OR = 1.7, p = 0.014) and visual interpretation of regional nodes via ¹⁸F-FDG PET (OR = 2.5, p = 0.026) independently predicted pathological regional lymph node metastasis. The areas under the receiver-operating-characteristic curves were 0.631, 0.671, and 0.711 for visual interpretation, primary tumor entropy, and their combination, respectively. Based on visual interpretation, a primary tumor entropy ≥ 3.0 improved the positive predictive value of positive visual interpretation from 51.2% to 63.0%, whereas an entropy < 3.0 improved the negative predictive value of negative visual interpretation from 75.3% to 82.6%. In cases with positive visual interpretation and low entropy, or negative visual interpretation and high entropy, the nodal metastasis rates were approximately 30%. In the survival analyses, the primary tumor entropy was also independently associated with DFS (HR = 2.7, p = 0.001) and OS (HR = 4.8, p = 0.001).

Conclusions: Our preliminary results show that the primary tumor entropy may improve ¹⁸F-FDG PET visual interpretation in predicting pathological nodal metastasis in lung adenocarcinoma, and may also show a survival prognostic value. This versatile biomarker may facilitate tailored therapeutic strategies for patients with resectable lung adenocarcinoma.

Keywords: 18F-FDG PET; Entropy; Heterogeneity; Lung adenocarcinoma; Radiomics.