Testing Novel Inactivation Methods and Adjuvants for Vaccines Against Streptococcus agalactiae in Nile Tilapia Oreochromis niloticus

Fernando Carlos Ramos-Espinoza; Victor Alexander Cueva-Quiroz; Jefferson Yunis-Aguinaga; Norquis Caled Alvarez-Rubio; Nicoli Paganoti de Mello; Julieta Rodini Engrácia de Moraes

doi:10.1007/978-1-0716-1888-2_14

Testing Novel Inactivation Methods and Adjuvants for Vaccines Against Streptococcus agalactiae in Nile Tilapia Oreochromis niloticus

Methods Mol Biol. 2022:2411:241-249. doi: 10.1007/978-1-0716-1888-2_14.

Authors

Fernando Carlos Ramos-Espinoza¹, Victor Alexander Cueva-Quiroz², Jefferson Yunis-Aguinaga², Norquis Caled Alvarez-Rubio², Nicoli Paganoti de Mello², Julieta Rodini Engrácia de Moraes²

Affiliations

¹ Aquaculture Center of Unesp (Caunesp), São Paulo State University (Unesp), Jaboticabal, SP, Brazil. fernando.ramos@unesp.br.
² Aquaculture Center of Unesp (Caunesp), São Paulo State University (Unesp), Jaboticabal, SP, Brazil.

PMID: 34816409
DOI: 10.1007/978-1-0716-1888-2_14

Abstract

Inactivation by hydrogen peroxide and pH manipulation are two novel methods used recently in experimental vaccines against Streptococcus agalactiae in Nile tilapia. Here we describe in detail inactivation using novel methods as well as the classical method of inactivation. These vaccines showed similar moderate efficacy when compared to the conventional formaldehyde vaccine. In addition, we describe the inclusion of adjuvants in a hydrogen peroxide vaccine.

Keywords: Aluminum hydroxide; Bacterial inactivation; Hydrogen peroxide; Streptococcosis; Vaccination.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adjuvants, Immunologic / pharmacology
Animals
Cichlids*
Fish Diseases* / prevention & control
Hydrogen Peroxide
Streptococcal Infections* / prevention & control
Streptococcal Infections* / veterinary
Streptococcal Vaccines*
Streptococcus agalactiae* / immunology

Substances

Adjuvants, Immunologic
Streptococcal Vaccines
Hydrogen Peroxide