Proteolysis-targeting chimeras: a kaleidoscope of targeted protein degradation

Future Med Chem. 2022 Jan;14(3):139-141. doi: 10.4155/fmc-2021-0199. Epub 2021 Nov 24.

Authors

Yi Mou¹, Shuai Wen¹, Xinxing Gao¹, Zheng-Yu Jiang²

Affiliations

¹ College of Pharmacy and Chemistry and Chemical Engineering, Taizhou University, Taizhou, 225300, China.
² Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, 210009, China.

PMID: 34814705
DOI: 10.4155/fmc-2021-0199

No abstract available

Keywords: E3 ligase; PROTAC; targeted protein degradation.

Publication types

Editorial
Research Support, Non-U.S. Gov't

MeSH terms

Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology*
Humans
Proteolysis / drug effects*
Ubiquitin-Protein Ligases / antagonists & inhibitors*
Ubiquitin-Protein Ligases / metabolism

Substances

Enzyme Inhibitors
Ubiquitin-Protein Ligases