Objective: To understand the prevalence and correlates of plasma cytomegalovirus (CMV) viremia among HIV-infected individuals by Meta-analysis. Methods: A systematic literature retrieval was conducted by PubMed, CNKI, Wanfang, and VIP databases for the information about the prevalence of plasma CMV viremia among HIV-infected individuals published from 2011 to 2020. Meta-analysis was used to calculate the pooled prevalence after literature screening and data extraction. Results: Fifteen studies were included, and the total sample size was 5 076. The random effect model showed that the pooled prevalence of CMV viremia among HIV-infected individuals was 26.2% (95%CI: 16.8%-35.6%, I2=99%); Subgroup analysis and Meta-regression showed that the sources of heterogeneity among different studies were: the proportion of individuals aged >30 years in sample, the proportion of homosexual transmission in the sample, the proportion of individuals whose HIV viral load > 104 copies/ml, the proportion of individuals whose CD4+T lymphocyte counts <200 cells/μl. Conclusion: Among HIV-infected individuals, the prevalence of CMV viremia was high and might be associated with age, HIV transmission mode, the status of HIV/AIDS.
目的： 运用Meta分析了解HIV感染者巨细胞病毒（CMV）血症的流行情况及相关因素。 方法： 系统检索2011-2020年PubMed、中国知网、万方数据知识服务平台、维普数据库中关于HIV感染者CMV血症现患率的文献，文献筛选和数据提取后进行Meta分析。 结果： 共纳入15篇文献，总样本量为5 076例。Meta随机效应模型显示，HIV感染者CMV血症合并现患率为26.2%（95%CI：16.8%~35.6%，I2=99%）；亚组分析和Meta回归结果显示，不同研究间异质性来源可能为：研究样本中>30岁人群比例、同性性传播比例、HIV病毒载量>104 拷贝数/ml比例、CD4+T淋巴细胞计数<200 个/μl比例。 结论： HIV感染者CMV血症现患率较高，现患CMV血症可能与HIV感染者的年龄、HIV感染途径、艾滋病病程进展密切相关。.