Genetic association analysis between IL9 and coronary artery disease in a Chinese Han population

Lingfeng Zha; Jiangtao Dong; Qianwen Chen; Yuhua Liao; Hongsong Zhang; Tian Xie; Tingting Tang; Ni Xia; Min Zhang; Jiao Jiao; Yingchao Zhou; Jianfei Wu; Xiangping Yang; Chengqi Xu; Qing K Wang; Xin Tu; Xiang Cheng; Shaofang Nie

doi:10.1016/j.cyto.2021.155761

Genetic association analysis between IL9 and coronary artery disease in a Chinese Han population

Cytokine. 2022 Feb:150:155761. doi: 10.1016/j.cyto.2021.155761. Epub 2021 Nov 20.

Authors

Lingfeng Zha¹, Jiangtao Dong², Qianwen Chen³, Yuhua Liao¹, Hongsong Zhang⁴, Tian Xie¹, Tingting Tang¹, Ni Xia¹, Min Zhang¹, Jiao Jiao¹, Yingchao Zhou⁵, Jianfei Wu⁵, Xiangping Yang⁶, Chengqi Xu⁵, Qing K Wang⁵, Xin Tu⁵, Xiang Cheng¹, Shaofang Nie⁷

Affiliations

¹ Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
² Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
³ Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Maternal and Child Health Hospital, Wuhan 430070, China.
⁴ Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210006, China.
⁵ Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Cardio-X Institute, Huazhong University of Science and Technology, Wuhan 430074, China.
⁶ School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
⁷ Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address: shaofangnie@hust.edu.cn.

PMID: 34814015
DOI: 10.1016/j.cyto.2021.155761

Abstract

Interleukin-9 (IL-9) plays important role in coronary artery disease (CAD). However, the exact relationship between them is not explored yet. Here, four tag SNPs covering IL9 (rs31563, rs2069868, rs2069870 and rs31564) were selected to conduct case-control association analyses in a total of 3704 individuals from Chinese Han population (1863 CAD vs 1841 control). Results showed that: first, rs2069868 was associated with CAD combined with hypertension (P_adj = 0.027); second, IL9 haplotype (CGAT) was associated with CAD (P_adj = 0.035), and the combination genotype of "rs31563_CC/rs31564_TT" would remarkably decrease the risk of CAD (P_adj = 0.001); third, significant associations were found between rs2069870 and decreased LDL-c levels and decreased total cholesterol levels, and between rs31563 and increased HDL-c levels (P_adj < 0.05). Therefore, we conclude that IL9 might play a causal role in CAD by interacted with CAD traditional risk factors, which might confer a new way to improve the prevention and treatment of CAD.

Keywords: Association analysis; Coronary artery disease (CAD); Haplotype; IL9; Single-nucleotide polymorphisms (SNPs).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Asian People / genetics
Case-Control Studies
China / epidemiology
Coronary Artery Disease* / genetics
Ethnicity
Genetic Predisposition to Disease
Humans
Interleukin-9*
Polymorphism, Single Nucleotide / genetics
Risk Factors

Substances

Interleukin-9