Hematopoietic Progenitor Cell Donation from Healthy Female Donors During Pregnancy: A Report of 10 Cases

Abstract

The golden rule when collecting hematopoietic progenitors (HPs) from healthy volunteers is "donor safety." Pregnancy is an absolute contraindication for HP collection from unrelated donors; however, collection from a related pregnant donor is sometimes considered based on the urgency of the indication for transplantation and the available alternatives. Data on the safety and efficacy of this practice are limited. We conducted a retrospective chart review of an institution's transplantation database to characterize the safety and efficacy of HP donation from pregnant donors. Ten cases of HP donation from pregnant donors were identified, including 6 bone marrow grafts and 4 peripheral blood stem cell grafts. The median age of donors was 27.5 years. The median volume of the collected product was 521 mL (range, 128 to 1160 mL), the median number of total nucleated cells (TNCs) in the graft was 252 × 10⁸ (range, 30.5 to 794 × 10⁸), the median TNC concentration in the graft was 37 × 10⁶ per mL (range, 4.7 to 214.6 × 10⁶ per mL). The median number of CD34 cells in the graft was 142 × 10⁶ (range, 6 to 763 × 10⁶), and the median CD34 concentration in the graft was 20 × 10⁴ per mL (range, 2 to 206 × 10⁴ per mL). There were no safety issues or signals related to the procedure. HP collection from pregnant donors is relatively safe. This case series provides valuable information for practicing transplant physicians on how to counsel pregnant donors when this scenario is encountered in clinical practice.

Keywords: Cell donation during pregnancy; Hematopoietic cell transplantation; Pregnancy; Stem cell donor.