Comparison of clinical, laboratory and radiological features in confirmed and unconfirmed COVID-19 patients

Future Microbiol. 2021 Dec:16:1389-1400. doi: 10.2217/fmb-2021-0162. Epub 2021 Nov 23.

Abstract

Background: We aimed to compare the clinical, laboratory and radiological findings of confirmed COVID-19 and unconfirmed patients. Methods: This was a single-center, retrospective study. Results: Overall, 620 patients (338 confirmed COVID-19 and 282 unconfirmed) were included. Confirmed COVID-19 patients had higher percentages of close contact with a confirmed or probable case. In univariate analysis, the presence of myalgia and dyspnea, decreased leukocyte, neutrophil and platelet counts were best predictors for SARS-CoV-2 RT-PCR positivity. Multivariate analyses revealed that only platelet count was an independent predictor for SARS-CoV-2 RT-PCR positivity. Conclusion: Routine complete blood count may be helpful for distinguishing COVID-19 from other respiratory illnesses at an early stage, while PCR testing is unique for the diagnosis of COVID-19.

Keywords: COVID-19; SARS-CoV-2 PCR; close contact; complete blood count; diagnosis; platelet.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Blood Cell Count
  • COVID-19 / blood
  • COVID-19 / diagnosis*
  • COVID-19 / diagnostic imaging
  • COVID-19 / virology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Radiography
  • Retrospective Studies
  • SARS-CoV-2 / classification
  • SARS-CoV-2 / genetics
  • SARS-CoV-2 / isolation & purification
  • Thorax / diagnostic imaging
  • Tomography, X-Ray Computed
  • Young Adult