A controllable and regiodivergent N-allylation reaction involving readily available O-alkyl hydroxamates derived from natural α-amino acids has been developed, allowing regiospecific access to α/β-dipeptides containing α-unsaturated β-amino acids moieties in moderate to good yields. The regioselectivity could be conveniently switched by alternation of the catalysts and solvents.
Keywords: Morita-Baylis-Hillman carbonate; allylation; regiodivergent synthesis; synthetic methods; α/β-dipeptide.
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