Network pharmacology-based analysis of the anti-hyperglycemic active ingredients of roselle and experimental validation

Bingxuan Niu; Xu Xie; Xiaoming Xiong; Junlin Jiang

doi:10.1016/j.compbiomed.2021.104636

Network pharmacology-based analysis of the anti-hyperglycemic active ingredients of roselle and experimental validation

Comput Biol Med. 2022 Feb:141:104636. doi: 10.1016/j.compbiomed.2021.104636. Epub 2021 Jul 27.

Authors

Bingxuan Niu¹, Xu Xie², Xiaoming Xiong², Junlin Jiang³

Affiliations

¹ Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, 410078, China; Collage of Pharmacy, Xinxiang Medical University, Xinxiang, Henan Province, 453002, China. Electronic address: nbx@xxmu.edu.cn.
² Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, 410078, China.
³ Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, 410078, China; Hunan Provincial Key Laboratory of Cardiovascular Research, Central South University, Changsha, 410078, China. Electronic address: junlinjiang@csu.edu.cn.

PMID: 34809966
DOI: 10.1016/j.compbiomed.2021.104636

Abstract

Diabetes mellitus is one of the top four leading causes of death among noncommunicable diseases worldwide, according to the World Hibiscus sabdariffa 2019. Roselle (Hibiscus sabdariffa L.), a traditional herbal medicine, has shown significant clinical anti-hyperglycemic efficacy. However, the mechanism of the treatment is not yet clear. We found that Roselle has a certain protective effect on vascular endothelial cells through this study. This study was based on network pharmacology and experimental validation. The present study made a comprehensive analysis by combining active ingredient screening, target prediction and signaling pathway analysis to elucidate the active ingredients and possible molecular mechanism of roselle for the first time, which provided theoretical and experimental basis for the development and application of roselle as an antidiabetic drug.

Keywords: Active ingredients; HIF-1α signaling pathway; Hyperglycemia; Network pharmacology; Roselle.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Endothelial Cells
Hibiscus*
Hypoglycemic Agents / pharmacology
Hypoglycemic Agents / therapeutic use
Network Pharmacology
Plant Extracts / pharmacology
Plant Extracts / therapeutic use

Substances

Hypoglycemic Agents
Plant Extracts