Left Heart Disease-Related Pulmonary Hypertension

Ayedh K Alamri; Christy L Ma; John J Ryan

doi:10.1016/j.ccl.2021.08.007

Left Heart Disease-Related Pulmonary Hypertension

Cardiol Clin. 2022 Feb;40(1):69-76. doi: 10.1016/j.ccl.2021.08.007.

Authors

Ayedh K Alamri¹, Christy L Ma², John J Ryan³

Affiliations

¹ Department of Medicine, University of Utah, University of Utah School of Medicine, 30 North 1900 East, Room 4C116, Salt Lake City, UT 84132, USA.
² Division of Cardiovascular Medicine, Department of Medicine, University of Utah, University of Utah School of Medicine, 30 North 1900 East, Room 4A100, Salt Lake City, UT 84132, USA.
³ Division of Cardiovascular Medicine, Department of Medicine, University of Utah, University of Utah School of Medicine, 30 North 1900 East, Room 4A100, Salt Lake City, UT 84132, USA. Electronic address: john.ryan@hsc.utah.edu.

PMID: 34809918
DOI: 10.1016/j.ccl.2021.08.007

Abstract

Pulmonary hypertension (PH) due to left heart disease (LHD; group 2 PH) is a common complication of heart failure with reduced ejection fraction and heart failure with preserved ejection fraction and is often related to disease severity and duration of these diseases. PH due to LHD is associated with negative impact on outcomes in addition to worse symptoms and exercise capacity. Risk factors for group 2 PH are older age, hypertension, atrial fibrillation, and features of metabolic syndrome. The main mechanisms for group 2 PH are believed to be vascular remodeling secondary to sustained elevated intravascular pressure.

Keywords: Diastolic dysfunction; Heart failure; Hemodynamics; Postcapillary; Precapillary.

Publication types

Review

MeSH terms

Aged
Heart Diseases*
Heart Failure* / epidemiology
Heart Failure* / etiology
Humans
Hypertension, Pulmonary* / diagnosis
Hypertension, Pulmonary* / epidemiology
Hypertension, Pulmonary* / etiology
Risk Factors
Stroke Volume
Ventricular Dysfunction, Left*