The imaging quality of infrared detection systems over time directly affects their ability to track targets accurately. In this study, a prediction scheme for the image quality of infrared detection system under hypersonic conditions based on time accuracy has been developed. Further, based on the time discretization, a calculation model has been established for the prediction scheme to perform numerical simulation. In particular, for verifying the reliability of this prediction method and the associated numerical calculation model, a comparison has been made between the numerical simulation results and the wind tunnel test results. The maximum error of the comparison result is less than 4.5%, and the reliability of the method proposed in this paper has been proved.