China county-based prostate specific antigen screening for prostate cancer and a cost-effective analysis

Zhiguo Zhang; Guoshu Liang; Peng Zhang; Zhongqi Zhao; Zhongnan He; Fengzhen Luo; Zhenqing Chen; Zongke Yang; Zhijie Zhang; Tao Xia; Xin Liu; Yong Zhang; Wei Ye

doi:10.21037/tau-21-779

China county-based prostate specific antigen screening for prostate cancer and a cost-effective analysis

Transl Androl Urol. 2021 Oct;10(10):3787-3799. doi: 10.21037/tau-21-779.

Authors

Zhiguo Zhang^#¹, Guoshu Liang^#², Peng Zhang³, Zhongqi Zhao⁴, Zhongnan He⁵, Fengzhen Luo⁶, Zhenqing Chen⁷, Zongke Yang⁸, Zhijie Zhang⁹, Tao Xia¹⁰, Xin Liu¹¹, Yong Zhang¹, Wei Ye²

Affiliations

¹ Department of Urology, Liuyang People's Hospital, Liuyang, China.
² Department of Urology, Guanghan People's Hospital, Guanghan, China.
³ Department of Urology, Xinmi Hospital of T.C.M, Xinmi, China.
⁴ Department of Urology, Pucheng County Hospital, Weinan, China.
⁵ Department of Urology, Ruichang People's Hospital, Ruichang, China.
⁶ Department of Urology, The People's Hospital of Yudu County, Ganzhou, China.
⁷ Department of Urology, Xunxian People's Hospital, Hebi, China.
⁸ Department of Urology, Dianjiang People's Hospital, Dianjiang, China.
⁹ Department of Urology, The Second Hospital of Qinhuangdao, Qinhuangdao, China.
¹⁰ Department of Urology, Chengcheng County Hospital, Weinan, China.
¹¹ Department of General Surgery, Linzhou People's Hospital, Linzhou, China.

^# Contributed equally.

Abstract

Background: Prostate cancer is one of the most common malignant tumors worldwide, and is the third-leading cause of cancer death in men. Nearly 70% of new prostate cancer patients in China are locally advanced or widely metastatic with poor prognosis. Providing active treatment to early stage prostate cancer patients can improve the prognosis of prostate cancer patients. Thus, this study sought to evaluate the economy of early prostate specific antigen (PSA) screening for high-risk prostate cancer.

Methods: Based on the data collected from the PSA screening activities of 11 county hospitals from October 2019 to April 2021, this study evaluated a high-risk prostate cancer population who received PSA screening and their quality of life and economy. The screening population comprised males aged over 50 years. All screening patients were tested for PSA. If the PSA value is unnormal, a further diagnosis based on magnetic resonance imagining (MRI) or a transrectal ultrasound-guided prostate biopsy were performed. The decision-tree and Markov model was used to simulate the process of disease development of high-risk prostate cancer patients who underwent screenings and those who did not, and the incremental cost-effectiveness ratio was also evaluated.

Results: A total of 13,726 men received a PSA screening. Of these, 1,062 men had abnormal PSA values, and 73 of these were diagnosed with prostate cancer. Of these 73 patients, 40, 21, and 12 had early stage, mid-stage, and late-stage prostate cancer, respectively. Compared to the patients unscreened, the 1,000 patients who received an early PSA screening increased their quality-adjusted life year (QALY) by 15.69 years; however, each QALY had an additional cost of 38,550 yuan, which was lower than the willingness to pay threshold of 72,447 yuan (per capita gross domestic product in 2020).

Conclusions: For high-risk prostate cancer patients, early screenings have a cost-effective advantage over no screenings. Thus, early screening should be vigorously promoted for high-risk prostate cancer patients.

Keywords: China; Prostate cancer; cost-effectiveness analysis; screening.