Natural sweetener Stevia rebaudiana: Functionalities, health benefits and potential risks

EXCLI J. 2021 Sep 22:20:1412-1430. doi: 10.17179/excli2021-4211. eCollection 2021.

Abstract

Stevia rebaudiana is a South American plant, the cultivation of which is increasing worldwide due to its high content of sweet compounds. Stevia sweetness is mainly due to steviol glycosides, that are ~250-300 times sweeter than sucrose. Many studies have suggested the benefits of Stevia extract over sugar and artificial sweeteners, but it is still not a very popular sugar substitute. This review summarizes current data on the biological activities of S. rebaudiana extract and its individual glycosides, including anti-hypertensive, anti-obesity, anti-diabetic, antioxidant, anti-cancer, anti-inflammatory, and antimicrobial effects and improvement of kidney function. Possible side effects and toxicity of Stevia extract are also discussed.

Keywords: Stevia rebaudiana; health benefits; rebaudioside A; stevioside; sweetener.

Publication types

  • Review