Factors associated with antibiotic administration delay among preterm infants with late-onset bloodstream infection

M Baczynski; A Kharrat; F Zhu; X Y Ye; P S Shah; D E Weisz; A Jain

doi:10.1016/j.jhin.2021.09.026

Factors associated with antibiotic administration delay among preterm infants with late-onset bloodstream infection

J Hosp Infect. 2022 Feb:120:31-35. doi: 10.1016/j.jhin.2021.09.026. Epub 2021 Nov 17.

Authors

M Baczynski¹, A Kharrat², F Zhu³, X Y Ye⁴, P S Shah⁵, D E Weisz⁶, A Jain⁷

Affiliations

¹ Department of Respiratory Therapy, Mount Sinai Hospital, Toronto, ON, Canada.
² Department of Paediatrics, University of Toronto, Toronto, ON, Canada; Department of Paediatrics, Mount Sinai Hospital, Toronto, ON, Canada.
³ Department of Paediatrics, University of Toronto, Toronto, ON, Canada.
⁴ Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
⁵ Department of Paediatrics, University of Toronto, Toronto, ON, Canada; Department of Paediatrics, Mount Sinai Hospital, Toronto, ON, Canada; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
⁶ Department of Paediatrics, University of Toronto, Toronto, ON, Canada; Department of Newborn and Developmental Paediatrics, Sunnybrook Health Science Center, Toronto, ON, Canada.
⁷ Department of Paediatrics, University of Toronto, Toronto, ON, Canada; Department of Paediatrics, Mount Sinai Hospital, Toronto, ON, Canada; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada; Department of Physiology, University of Toronto, Toronto, ON, Canada. Electronic address: amish.jain@sinaihealth.ca.

PMID: 34800611
DOI: 10.1016/j.jhin.2021.09.026

Abstract

Early antibiotic administration is an important modifiable factor in reducing mortality from late-onset bloodstream infections in preterm infants. In a cohort study including 142 infants with non-coagulase negative staphylococcus bloodstream infection at two tertiary neonatal intensive care units, we identified typical practice-related factors that may be targeted to prevent delays in antibiotic administration. Collection of cerebrospinal fluid or urine sample before administering antibiotics, a longer time taken to site a peripheral intravenous catheter among those without pre-existing access, and a longer time taken to administer fluid boluses were associated with a longer than median time to antibiotic administration.

Keywords: Antibiotic administration delay; Late-onset bloodstream infection; Neonatal intensive care unit; Practice-related factors; Preterm infants; Quality improvement.

MeSH terms

Anti-Bacterial Agents / therapeutic use
Cohort Studies
Humans
Infant
Infant, Newborn
Infant, Premature*
Intensive Care Units, Neonatal
Sepsis* / drug therapy
Sepsis* / prevention & control

Substances

Anti-Bacterial Agents