Topical Coagulant Agents

Olabisi Ololade Sheppard; Nathan Alan Foje

doi:10.1016/j.suc.2021.09.004

Topical Coagulant Agents

Surg Clin North Am. 2022 Feb;102(1):65-83. doi: 10.1016/j.suc.2021.09.004.

Authors

Olabisi Ololade Sheppard¹, Nathan Alan Foje²

Affiliations

¹ Division of Acute Care Surgery, Department of Surgery, University of Nebraska Medical Center, 983280 Nebraska Medical Center, Omaha, NE 68198, USA. Electronic address: Olabisi.Sheppard@unmc.edu.
² Department of Surgery, University of Nebraska Medical Center, 983280 Nebraska Medical Center, Omaha, NE 68198, USA.

PMID: 34800390
DOI: 10.1016/j.suc.2021.09.004

Abstract

Topical hemostatic agents have continued to develop as knowledge of coagulation physiology and pathophysiology has evolved. The addition of knowledge of hemostatic agents to a surgeon's armamentarium helps to push the boundaries of life-saving care. As the understanding of the complex physiology of coagulation and hemorrhage improves, so will the potential for developing hemostatic agents that are safe, affordable, and readily available. This article discusses topical coagulant agents and hemostatic materials currently available in the surgery. The relevant agents/materials, their characteristics, different utility in surgical hemostasis, and their relevant benefits and drawbacks are reviewed.

Keywords: Chitin; Chitosan; Combat gauze; Fibrinogen; Hemostatic agents; Surgical hemostasis; Thrombin; Topical coagulant agents.

Publication types

Review

MeSH terms

Administration, Topical
Bandages
Blood Loss, Surgical / prevention & control*
Hemostasis, Surgical / instrumentation
Hemostasis, Surgical / methods*
Hemostatics / administration & dosage*
Hemostatics / therapeutic use
Humans
Tissue Adhesives / administration & dosage
Tissue Adhesives / therapeutic use

Substances

Hemostatics
Tissue Adhesives