Isoquinoline alkaloid dimers with dopamine D1 receptor activities from Menispermum dauricum DC

Phytochemistry. 2022 Feb:194:113015. doi: 10.1016/j.phytochem.2021.113015. Epub 2021 Nov 16.

Abstract

A phytochemical investigation on chemical constituents from the rhizomes of Menispermum dauricum DC. identified eight undescribed dimeric alkaloids with structurally diverse monomeric isoquinoline. Alkaloid structures were elucidated by a combination of spectroscopic data analyses and time-dependent density functional theory (TDDFT) ECD calculation. The isolates were evaluated for inhibitory effect on dopamine D1 receptor and compound 1 exhibited potent D1 receptor antagonistic activity with an IC50 value of 8.4 ± 2.0 μM.

Keywords: D1 antagonistic activity; Dimeric isoquinoline alkaloids; Electronic circular dichroism; Menispermaceae; Menispermum dauricum DC..

MeSH terms

  • Alkaloids* / pharmacology
  • Isoquinolines* / pharmacology
  • Menispermum* / chemistry
  • Phytochemicals / pharmacology
  • Receptors, Dopamine D1 / antagonists & inhibitors*

Substances

  • Alkaloids
  • Isoquinolines
  • Phytochemicals
  • Receptors, Dopamine D1