Chemical, biological, radiological, and nuclear mass casualty medicine: a review of lessons from the Salisbury and Amesbury Novichok nerve agent incidents

Br J Anaesth. 2022 Feb;128(2):e200-e205. doi: 10.1016/j.bja.2021.10.008. Epub 2021 Nov 16.

Abstract

On March 4, 2018, two casualties collapsed on a park bench in Salisbury, Wiltshire, UK. They were later discovered to have been the victims of an attempted murder using the Soviet-era Novichok class of nerve agent. The casualties, along with three further critically ill patients, were cared for in Salisbury District Hospital's Intensive Care Unit. Before the COVID-19 pandemic, the Salisbury and Amesbury incidents were the longest-running major incidents in the history of the UK National Health Service. This narrative review seeks to reflect on the lessons learned from these chemical incidents, with a particular focus on hospital and local organisational responses.

Keywords: CBRN incident; Novichok; major incident; mass casualty incident; nerve agent; organophosphate poisoning.

Publication types

  • Review

MeSH terms

  • Biological Factors / poisoning
  • Chemical Hazard Release / prevention & control*
  • Emergency Medical Services / methods*
  • Humans
  • Incidence
  • Mass Casualty Incidents / prevention & control*
  • Nerve Agents / poisoning*
  • Organophosphates / toxicity*
  • Personal Protective Equipment*
  • Radioactive Hazard Release / prevention & control
  • Radiologic Health
  • United Kingdom / epidemiology

Substances

  • Biological Factors
  • Nerve Agents
  • Organophosphates
  • novichok