Rifampicin-Induced Nephrotoxicity in a Tuberculosis Patient: Treatment Dilemma?

António Grilo Novais; Cláudio Silva; Ana Rita Coelho; Roberto Silva; Ana Cláudia Carvalho

doi:10.12890/2021_002833

Rifampicin-Induced Nephrotoxicity in a Tuberculosis Patient: Treatment Dilemma?

Eur J Case Rep Intern Med. 2021 Oct 14;8(10):002833. doi: 10.12890/2021_002833. eCollection 2021.

Authors

António Grilo Novais¹, Cláudio Silva², Ana Rita Coelho³, Roberto Silva³, Ana Cláudia Carvalho⁴

Affiliations

¹ Internal Medicine Department, Centro Hospitalar Tondela-Viseu, E.P.E, Portugal.
² Infectious Diseases Department, Centro Hospitalar Universitário São João, Porto, Portugal.
³ Pathology Department, Centro Hospitalar Universitário São João, Porto, Portugal.
⁴ Infectious Diseases Department, Hospital de Braga, Braga, Portugal.

Abstract

Acute kidney injury related to rifampin is usually a clinical diagnosis. We report a case of a man being treated for pulmonary tuberculosis with acute tubulointerstitial nephritis related to rifampicin.

Learning points: Rifampicin can cause acute kidney injury.Renal impairment may develop weeks after rifampicin administration was started.

Keywords: Acute tubulointerstitial nephritis; rifampicin-induced; tuberculosis.