Needle-Free Jet Injectors' Geometry Design and Drug Diffusion Process Analysis

Yunfei Wang; Long Yue; Lechuan Hu; Jing Wang

doi:10.1155/2021/5199278

Needle-Free Jet Injectors' Geometry Design and Drug Diffusion Process Analysis

Appl Bionics Biomech. 2021 Nov 8:2021:5199278. doi: 10.1155/2021/5199278. eCollection 2021.

Authors

Yunfei Wang¹, Long Yue¹, Lechuan Hu², Jing Wang³

Affiliations

¹ School of Transportation and Vehicle Engineering, Shandong University of Technology, Zibo 255000, China.
² School of Energy and Power Engineering, Shandong University, Jinan 250061, China.
³ School of Clinical Medicine, Qilu Medical University, Zibo 255300, China.

Abstract

In order to study the injection and diffusion process of the drug in the subcutaneous tissue of a needle-free jet injectors (NFJIs) in detail and understand the influence of different nozzle geometry on the diffusion process of the drug, in this paper, numerical simulations were performed to study the diffusion process of the drug in the subcutaneous tissue of NFJIs with cylindrical nozzle. On this basis, the differences of the drug diffusion process with different nozzle geometries were analyzed. The results show that the drug diffused in the shape of ellipsoid in the subcutaneous tissue. The penetration of the drug into the subcutaneous tissue is deeper under the condition of conical nozzle and conical cylindrical nozzle at the same time. However, it takes longer to spread to the interface between skin and subcutaneous tissue in reverse.