A case with SARS-CoV-2 reinfection from India

Ashok Munivenkatappa; Rima R Sahay; Gururaj R Deshpande; Deepak Y Patil; Anita M Shete; Gajanan N Sapkal; Ravish Kumar; Marappa Narayana; Pragya D Yadav; Vijay Shettar

doi:10.1016/j.ijmmb.2021.09.010

A case with SARS-CoV-2 reinfection from India

Indian J Med Microbiol. 2022 Jan-Mar;40(1):166-168. doi: 10.1016/j.ijmmb.2021.09.010. Epub 2021 Nov 15.

Authors

Affiliations

¹ Indian Council of Medical Research-National Institute of Virology, Bangalore Unit, Karnataka, 560029, India. Electronic address: ashokmniv@gmail.com.
² Indian Council of Medical Research-National Institute of Virology, Pune, Maharashtra, 411021, India. Electronic address: dr.rima.sahay@gmail.com.
³ Indian Council of Medical Research-National Institute of Virology, Pune, Maharashtra, 411021, India. Electronic address: gndeshpande@gmail.com.
⁴ Indian Council of Medical Research-National Institute of Virology, Pune, Maharashtra, 411021, India. Electronic address: patildeepak8@gmail.com.
⁵ Indian Council of Medical Research-National Institute of Virology, Pune, Maharashtra, 411021, India. Electronic address: anitaaich2008@gmail.com.
⁶ Indian Council of Medical Research-National Institute of Virology, Pune, Maharashtra, 411021, India. Electronic address: gajanansapkalniv@gmail.com.
⁷ Employees' State Insurance Corporation Medical College and Hospital, Gulbarga, Karnataka, 585106, India. Electronic address: drravish@rocketmail.com.
⁸ Employees' State Insurance Corporation Medical College and Hospital, Gulbarga, Karnataka, 585106, India. Electronic address: marappa003@gmail.com.
⁹ Indian Council of Medical Research-National Institute of Virology, Pune, Maharashtra, 411021, India. Electronic address: hellopragya22@gmail.com.
¹⁰ Employees' State Insurance Corporation Medical College and Hospital, Gulbarga, Karnataka, 585106, India. Electronic address: shettarv@gmail.com.

Abstract

A healthcare worker presented with fever, cough, headache and tested positive by SARS-CoV-2 real time reverse transcriptase polymerase chain reaction (qRT-PCR). He got admitted to hospital and recovered after 14 days. After 2 months, as a screening protocol considering the high risk setup he got tested and again found to be positive for SARS-CoV-2 by qRT-PCR. Our patient had detectable levels of Anti-SARS-CoV-2 IgG antibodies during the reinfection but found negative for Neutralizing antibodies (NAb). Our findings suggest that the person after the initial infection might not develop the desired protective immunity to prevent the reinfection as demonstrated by absence of NAb.

Keywords: COVID-19; IgG antibodies; India; Reinfection; SARS-CoV-2.

Publication types

Case Reports

MeSH terms

Antibodies, Neutralizing
Antibodies, Viral
COVID-19* / diagnosis
Humans
Male
Reinfection / diagnosis
SARS-CoV-2*

Substances

Antibodies, Neutralizing
Antibodies, Viral