Bartonella spp. seroepidemiology and associations with clinicopathologic findings in dogs in the United States

Abstract

Background: Improved understanding of Bartonella spp. serology in dogs may aid clinical decision making.

Objective: Describe demographic and geographic patterns of Bartonella spp. seroreactivity in dogs, and describe hematologic and serum biochemical abnormalities in Bartonella spp. seroreactive and nonseroreactive dogs.

Animals: Serum samples from 5957 dogs in the United States, previously submitted to IDEXX Reference Laboratories.

Methods: Serum was tested using 3 indirect ELISAs for B. henselae, B. vinsonii subsp. berkhoffii, and B. koehlerae. Complete blood count and serum biochemistry panel results were reviewed retrospectively.

Results: Overall, 6.1% of dogs were Bartonella spp. seroreactive. Toy breeds were less likely to be seroreactive (3.9%) than mixed breeds (7.5%; adjusted odds ratio [aOR], 0.48; 95% confidence interval [CI], 0.32-0.72), and dogs <1 year old were less likely to be seroreactive (3.4%) than dogs 1 to 5.5 years of age (7.3%; aOR, 0.42; 95% CI, 0.23-0.72). Dogs in the West South Central (9.8%) and South Atlantic (8.8%) regions were more likely than dogs elsewhere in the United States to be seroreactive (aOR, 2.22; 95% CI, 1.31-3.87; aOR, 2.44; 95% CI, 1.38-4.36).

Conclusions and clinical importance: Demographic and geographic findings for Bartonella spp. exposure were broadly comparable to previously reported patterns.

Keywords: bartonellosis; canine; seroreactivity; vector-borne; zoonoses.