Pneumocystis jirovecii pneumonia in a X-linked chronic granulomatous disease female carrier

Vasiliki Kalotychou; Demetrios Mermigkis; Maria G Kanariou; Marianna Tzanoudaki; Vasiliki Epameinondas Georgakopoulou; Irene Kourbeti; George L Daikos

doi:10.1016/j.idcr.2021.e01323

Pneumocystis jirovecii pneumonia in a X-linked chronic granulomatous disease female carrier

IDCases. 2021 Oct 27:26:e01323. doi: 10.1016/j.idcr.2021.e01323. eCollection 2021.

Authors

Vasiliki Kalotychou¹, Demetrios Mermigkis², Maria G Kanariou³, Marianna Tzanoudaki³, Vasiliki Epameinondas Georgakopoulou², Irene Kourbeti¹, George L Daikos¹

Affiliations

¹ First Department of Medicine, National and Kapodistrian University of Athens, Laikon, General Hospital, Greece.
² First Pulmonary Department, Sismanogleio General Hospital, Athens, Greece.
³ Department of Immunology-Histocompatibility, Specialized Center & Referral Center for Primary Immunodeficiencies-Paediatric Immunology, "Aghia Sophia" Children's Hospital, Athens, Greece.

Abstract

The X-chromosome linked (XL) female carriers of chronic granulomatous disease (CGD) are considered to have no risk for infection. Herein we present a female CGD XL-carrier who developed Pneumocystis jirovecii pneumonia and Serratia marcescens infection associated with age-related skewing of X-chromosome inactivation.

Keywords: Chronic Granulomatous Disease; Neutrophils’ oxidative activity; Pneumocystis jirovecii; X-chromosome inactivation; X-linked carrier.

Publication types

Case Reports