Antiviral and cytotoxic effects of a traditional drug KanthaRasaVillai with a cocktail of metallic nanoparticles

Amirtham J A Ranjitsingh; Sandhanasamy Devanesan; Mohamad S AlSalhi; Parameswari Paul; C Padmalatha

doi:10.1016/j.jksus.2021.101693

Antiviral and cytotoxic effects of a traditional drug KanthaRasaVillai with a cocktail of metallic nanoparticles

J King Saud Univ Sci. 2022 Jan;34(1):101693. doi: 10.1016/j.jksus.2021.101693. Epub 2021 Nov 12.

Authors

Amirtham J A Ranjitsingh¹, Sandhanasamy Devanesan², Mohamad S AlSalhi², Parameswari Paul³, C Padmalatha⁴

Affiliations

¹ Department of Biotechnology, Prathyusha Engineering College, Chennai 600056, India.
² Department of Physics and Astronomy, College of Science, King Saud University, P.O. Box-2455, Riyadh 11451, Saudi Arabia.
³ Department of Horticulture, Molecular Genetics and Genomics Laboratory, College of Agriculture and Life Science, Chungnam National University, Daejeon 34134, South Korea.
⁴ U G C Emeritus Fellow, MS University, India.

Abstract

Objective: Alternative medicine plays an important role today in searching for therapeutics for cancer and viral infection. So, a scientific validation to characterize constituents in the alternative medicines and therapeutic testing is warranted using modern instrumentation.

Methods: In the present study, an old herbomineral formulation, KanthaRasavillai [KRV], was characterized using UV-vis spectrometry, FT-IR, XRD, SEM, and TEM study. Also, In vitro and in vivo studies were done to evaluate their antiviral and anticancer activity. FT-IR and XRD studies revealed a cocktail of nanoparticles of mercury, magnetic oxide, cinnabar, and arsenic.Results.Based on SEM, TEM, and XRD report, KRV contains nanoparticles in the size range of 9.1 nm to 25.0 nm. FT-IR analysis exposed the presence of several anti-cancerous bioactive compounds.Further in vitro testing against HCV virus proved KRV to inhibit HCV virus a close relative to SARS-CoV-2. MTT assay confirmed the anticancer effect of KRV against Huh-7 and MCF-7 cell lines.

Conclusion: The anticancer and antiviral properties in the ancient herbomineral drug with a cocktail of metal nanoparticles acknowledge the traditional medical practice as a pioneering approach for present-day ailments. However, the study concludes that the use of KRV depends on safety dosage and genuine preparation as described by ancient saints.

Keywords: Antiviral and anticancer; Herbomineral; Kantha Rasavillai; Nanoparticles.