Return to Sports Following Meniscal Allograft Transplantation Is Possible but Remains Questionable: A Systematic Review

Abdulaziz F Ahmed; Joseph Rinaldi; Ali S Noorzad; Bashir A Zikria

doi:10.1016/j.arthro.2021.11.003

Return to Sports Following Meniscal Allograft Transplantation Is Possible but Remains Questionable: A Systematic Review

Arthroscopy. 2022 Apr;38(4):1351-1361. doi: 10.1016/j.arthro.2021.11.003. Epub 2021 Nov 14.

Authors

Abdulaziz F Ahmed¹, Joseph Rinaldi², Ali S Noorzad³, Bashir A Zikria⁴

Affiliations

¹ Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, U.S.A.
² Herbert Wertheim College of Medicine, Florida International University, Miami, FL, U.S.A.
³ Cedars-Sinai Medical Center, Los Angeles, CA, U.S.A.
⁴ Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, U.S.A.. Electronic address: bzikria2@jhmi.edu.

PMID: 34785295
DOI: 10.1016/j.arthro.2021.11.003

Abstract

Objective: To evaluate the return to sports rate and time following meniscal allograft transplantation (MAT).

Methods: PubMed, Web of Science, and Embase were searched in December 2020. Eligibility criteria included clinical studies reporting the return to sport rate following MAT with ≥12-month follow-up.

Results: A total of 14 case series were included with 670 patients. The bone bridge technique was used for all transplantations in 5 studies, and suture fixations with bone tunnels were used for all transplantations in 5 studies. In 2 studies, bone plugs were used for medial menisci and bone bridge for lateral menisci. In 1 study, suture fixation was used for medial menisci, and bone bridge for lateral menisci. The return to sports rate ranged from 20% to 91.7%, with 2 studies reporting low return to sport rates. The return to sport time ranged between 7.6 and 16.9 months. The return to preinjury level had a rate of 7% to 100%. Return to a higher level of sports was reported in only 2 studies (28.5% to 86%). Return to a lower level of sports was reported in low proportions in most studies. In terms of patient-reported outcomes, the Lysholm knee and subjective International Knee Documentation Committee (IKDC) scores and Knee Osteoarthritis Outcome Score (KOOS) had significant improvements after MAT. The KOOS quality of life subscore did not change significantly in 1 study. The total reoperation rate after MAT ranged between 3.1% and 80%, whereas the total failure ranged between 1.1% and 30.1%.

Conclusion: Despite that most studies reporting high return to sports rates, the current level of evidence is low, with all studies being case series. There is significant variability in the reported return to sports rate, time, and level. Therefore, high-quality comparative studies are mandated to elucidate whether MAT is associated with higher return to sports rates and levels.

Level of evidence: IV, systematic review.

Publication types

Review
Systematic Review

MeSH terms

Allografts
Follow-Up Studies
Humans
Menisci, Tibial / transplantation
Quality of Life*
Return to Sport*
Transplantation, Homologous