Prenatal particulate matter exposure and mitochondrial mutational load at the maternal-fetal interface: Effect modification by genetic ancestry

Kelly J Brunst; Hsiao-Hsien Leon Hsu; Li Zhang; Xiang Zhang; Kecia N Carroll; Allan Just; Brent A Coull; Itai Kloog; Robert O Wright; Andrea A Baccarelli; Rosalind J Wright

doi:10.1016/j.mito.2021.11.003

Prenatal particulate matter exposure and mitochondrial mutational load at the maternal-fetal interface: Effect modification by genetic ancestry

Mitochondrion. 2022 Jan:62:102-110. doi: 10.1016/j.mito.2021.11.003. Epub 2021 Nov 14.

Authors

Affiliations

¹ Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, 160 Panzeca Way, Cincinnati, OH 45267, USA. Electronic address: kelly.brunst@uc.edu.
² Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, 17 East 102(nd) St. New York, NY 10029, USA. Electronic address: leon.hsu@mssm.edu.
³ Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, 160 Panzeca Way, Cincinnati, OH 45267, USA. Electronic address: zhang3l3@ucmail.uc.edu.
⁴ Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, 160 Panzeca Way, Cincinnati, OH 45267, USA. Electronic address: xiang.zhang@ucmail.uc.edu.
⁵ Kravis Children's Hospital, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, 17 East 102(nd) St. New York, NY 10029, USA; Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, 17 East 102(nd) St., New York, NY 10029, USA. Electronic address: kecia.carroll@mssm.edu.
⁶ Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, 17 East 102(nd) St. New York, NY 10029, USA.
⁷ Department of Biostatistics, Harvard T.H. Chan School of Public Health, 655 Huntington Ave., Boston, MA 02115, USA. Electronic address: bcoull@hsph.harvard.edu.
⁸ Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, 17 East 102(nd) St. New York, NY 10029, USA; Department of Geography and Environmental Development, Ben-Gurion University of the Negev, P.O.B 653, Beer Sheva, Israel. Electronic address: ikloog@bgu.ac.il.
⁹ Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, 17 East 102(nd) St. New York, NY 10029, USA; Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, 17 East 102(nd) St., New York, NY 10029, USA. Electronic address: robert.wright@mssm.edu.
¹⁰ Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University Medical Center, 722 W 168(th) St. New York, NY 10032, USA. Electronic address: andrea.baccarelli@columbia.edu.
¹¹ Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, 17 East 102(nd) St. New York, NY 10029, USA; Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, 17 East 102(nd) St., New York, NY 10029, USA. Electronic address: rosalind.wright@mssm.edu.

Abstract

Prenatal ambient particulate matter (PM_2.5) exposure impacts infant development and alters placental mitochondrial DNA abundance. We investigated whether the timing of PM_2.5 exposure predicts placental mitochondrial mutational load using NextGen sequencing in 283 multi-ethnic mother-infant dyads. We observed increased PM_2.5exposure, particularly during mid- to late-pregnancy and among genes coding for NADH dehydrogenase and subunits of ATP synthase, was associated with a greater amount of nonsynonymous mutations. The strongest associations were observed for participants of African ancestry. Further work is needed to tease out the role of mitochondrial genetics and its impact on offspring development and emerging disease disparities.

Keywords: Air pollution; Bioenergetics; Mitochondria; Pregnancy.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Air Pollutants / adverse effects
DNA, Mitochondrial / genetics*
Female
Humans
Maternal-Fetal Exchange / physiology*
Mitochondria / drug effects*
Mitochondria / genetics
Mutation
Particulate Matter / toxicity*
Pregnancy
Prenatal Exposure Delayed Effects
Racial Groups / genetics*

Substances

Air Pollutants
DNA, Mitochondrial
Particulate Matter

Abstract

Publication types

MeSH terms

Substances

Grants and funding