Vitamin D: Skin, sunshine, and beyond

Erisa Alia; Philip E Kerr

doi:10.1016/j.clindermatol.2021.05.025

Vitamin D: Skin, sunshine, and beyond

Clin Dermatol. 2021 Sep-Oct;39(5):840-846. doi: 10.1016/j.clindermatol.2021.05.025. Epub 2021 May 23.

Authors

Erisa Alia¹, Philip E Kerr²

Affiliations

¹ Department of Dermatology, University of Connecticut School of Medicine, Farmington, Connecticut, USA.
² Department of Dermatology, University of Connecticut School of Medicine, Farmington, Connecticut, USA. Electronic address: pkerr@uchc.edu.

PMID: 34785011
DOI: 10.1016/j.clindermatol.2021.05.025

Abstract

Vitamin D is a steroid hormone of importance to the field of dermatology. Skin is unique in that it is the site of vitamin D synthesis upon sun exposure and a target organ for its activity. We explore the physiology and metabolic mechanism of action of vitamin D, as well as its effects on the skin. We also discuss the current evidence of the efficacy and safety of oral and topical vitamin D analogues on skin conditions such as psoriasis, atopic dermatitis, vitiligo, sunburn, actinic keratosis, and fibrosing skin disorders. Based on currently available scientific evidence, the National Academy of Medicine's recommended dietary allowance for vitamin D ranges from 400 IU to 800 IU daily based on age categories.

MeSH terms

Humans
Psoriasis* / drug therapy
Skin
Sunburn*
Vitamin D
Vitamins / therapeutic use

Substances

Vitamins
Vitamin D