Long Non-Coding RNA: A Potential Strategy for the Diagnosis and Treatment of Colorectal Cancer

Shanshan Chen; Yi Fang; Lingyu Sun; Ruonan He; Beihui He; Shuo Zhang

doi:10.3389/fonc.2021.762752

Long Non-Coding RNA: A Potential Strategy for the Diagnosis and Treatment of Colorectal Cancer

Front Oncol. 2021 Oct 27:11:762752. doi: 10.3389/fonc.2021.762752. eCollection 2021.

Authors

Shanshan Chen¹, Yi Fang^{1

2}, Lingyu Sun^{1

2}, Ruonan He², Beihui He¹, Shuo Zhang¹

Affiliations

¹ The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, China.
² The First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.

Abstract

Colorectal cancer (CRC), being one of the most commonly diagnosed cancers worldwide, endangers human health. Because the pathological mechanism of CRC is not fully understood, there are many challenges in the prevention, diagnosis, and treatment of this disease. Long non-coding RNAs (lncRNAs) have recently drawn great attention for their potential roles in the different stages of CRC formation, invasion, and progression, including regulation of molecular signaling pathways, apoptosis, autophagy, angiogenesis, tumor metabolism, immunological responses, cell cycle, and epithelial-mesenchymal transition (EMT). This review aims to discuss the potential mechanisms of several oncogenic lncRNAs, as well as several suppressor lncRNAs, in CRC occurrence and development to aid in the discovery of new methods for CRC diagnosis, treatment, and prognosis assessment.

Keywords: colorectal cancer; drug resistance; invasion; long non-coding RNA; metastasis; occurrence; proliferation.

Publication types

Review