The Role of GM130 in Nervous System Diseases

Bei Huang; Xihong Li; Xiaoshi Zhu

doi:10.3389/fneur.2021.743787

The Role of GM130 in Nervous System Diseases

Front Neurol. 2021 Oct 28:12:743787. doi: 10.3389/fneur.2021.743787. eCollection 2021.

Authors

Bei Huang^{1

2}, Xihong Li^{2

3}, Xiaoshi Zhu⁴

Affiliations

¹ Operational Management Office, West China Second University Hospital, Sichuan University, Chengdu, China.
² Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.
³ Emergency Department, West China Second University Hospital, Sichuan University, Chengdu, China.
⁴ Pediatric Intensive Care Unit, Sichuan Provincial People's Hospital, Chengdu, China.

Abstract

Golgi matrix protein 130 (GM130) is a Golgi-shaping protein located on the cis surface of the Golgi apparatus (GA). It is one of the most studied Golgin proteins so far. Its biological functions are involved in many aspects of life processes, including mitosis, autophagy, apoptosis, cell polarity, and directed migration at the cellular level, as well as intracellular lipid and protein transport, microtubule formation and assembly, lysosome function maintenance, and glycosylation modification. Mutation inactivation or loss of expression of GM130 has been detected in patients with different diseases. GM130 plays an important role in the development of the nervous system, but the studies on it are limited. This article reviewed the current research progress of GM130 in nervous system diseases. It summarized the physiological functions of GM130 in the occurrence and development of Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), microcephaly (MCPH), sepsis associated encephalopathy (SAE), and Ataxia, aiming to provide ideas for the further study of GM130 in nervous system disease detection and treatment.

Keywords: AD; ALS; GM130; MCPH; PD; SAE; ataxia; nervous system diseases.

Publication types

Review