Recent progress in metal-based molecular probes for optical bioimaging and biosensing

Yingying Ning; Guo-Qing Jin; Meng-Xin Wang; Song Gao; Jun-Long Zhang

doi:10.1016/j.cbpa.2021.102097

Recent progress in metal-based molecular probes for optical bioimaging and biosensing

Curr Opin Chem Biol. 2022 Feb:66:102097. doi: 10.1016/j.cbpa.2021.102097. Epub 2021 Nov 11.

Authors

Yingying Ning¹, Guo-Qing Jin², Meng-Xin Wang², Song Gao³, Jun-Long Zhang⁴

Affiliations

¹ Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, PR China; Athinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging (i(3)), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, 02129, USA.
² Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, PR China.
³ Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, PR China; Chemistry and Chemical Engineering Guangdong Laboratory, Shantou, 515031, PR China; Spin-X Institute, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510641, PR China; Guangdong-Hong Kong-Macao Joint Laboratory of Optoelectronic and Magnetic Functional Materials.
⁴ Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, PR China; Chemistry and Chemical Engineering Guangdong Laboratory, Shantou, 515031, PR China. Electronic address: zhangjunlong@pku.edu.cn.

PMID: 34775149
DOI: 10.1016/j.cbpa.2021.102097

Abstract

Biological imaging and biosensing from subcellular/cellular level to whole body have enabled non-invasive visualisation of molecular events during various biological and pathological processes, giving great contributions to the rapid and impressive advances in chemical biology, drug discovery, disease diagnosis and prognosis. Optical imaging features a series of merits, including convenience, high resolution, good sensitivity, low cost and the absence of ionizing radiation. Among different luminescent probes, metal-based molecules offer unique promise in optical bioimaging and biosensing in vitro and in vivo, arising from their small sizes, strong luminescence, large Stokes shifts, long lifetimes, high photostability and tunable toxicity. In this review, we aim to highlight the design of metal-based molecular probes from the standpoint of synthetic chemistry in the last 2 years for optical imaging, covering d-block transition metal and lanthanide complexes and multimodal imaging agents.

Keywords: Bioimaging; Biosensing; Lanthanides; Molecular probe; Transition metals.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biosensing Techniques*
Diagnostic Imaging
Lanthanoid Series Elements*
Luminescence
Molecular Probes
Transition Elements*

Substances

Lanthanoid Series Elements
Molecular Probes
Transition Elements