Life support for transitory exhausted CTLs

Asmaa Mohamed; Yina H Huang

doi:10.1016/j.it.2021.10.012

Life support for transitory exhausted CTLs

Trends Immunol. 2021 Dec;42(12):1057-1059. doi: 10.1016/j.it.2021.10.012. Epub 2021 Nov 9.

Authors

Asmaa Mohamed¹, Yina H Huang²

Affiliations

¹ Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
² Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA; Norris Cotton Cancer Center, Lebanon, NH, USA; Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA. Electronic address: yina@dartmouth.edu.

Abstract

Di Pilato et al. demonstrate that CXCR6 positions TCF-1^- transitory CD8⁺ cytotoxic lymphocytes (CTLs) with perivascular CCR7⁺ dendritic cells (DCs) within the tumor stroma to receive IL-15 survival signals. The requirement for CXCR6 and its strong prediction of overall patient survival highlight the importance of continued CTL-DC interactions in sustaining tumor immunity.

Keywords: CXCR6–CXCL16; DC3; IL-15 trans-presentation; perivascular niche; transitory effector T cell; tumor immunity.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

CD8-Positive T-Lymphocytes
Dendritic Cells
Humans
Neoplasms* / therapy
Signal Transduction
T-Lymphocytes, Cytotoxic*

Abstract

Publication types

MeSH terms

Grants and funding