Surface bone sarcomas: an update on current clinicopathological diagnosis and treatment

Olga Savvidou; Olympia Papakonstantinou; Eleftheria Lakiotaki; Ioannis Zafeiris; Dimitra Melissaridou; Pinelopi Korkolopoulou; Panayiotis J Papagelopoulos

doi:10.1302/2058-5241.6.210064

Surface bone sarcomas: an update on current clinicopathological diagnosis and treatment

EFORT Open Rev. 2021 Oct 19;6(10):905-917. doi: 10.1302/2058-5241.6.210064. eCollection 2021 Oct.

Authors

Olga Savvidou^{1

2}, Olympia Papakonstantinou^{3

2}, Eleftheria Lakiotaki^{4

2}, Ioannis Zafeiris¹, Dimitra Melissaridou¹, Pinelopi Korkolopoulou^{4

5}, Panayiotis J Papagelopoulos^{1

5}

Affiliations

¹ First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece.
² These authors contributed equally to this manuscript.
³ Second Department of Radiology, National and Kapodistrian University of Athens, Medical School, Attikon University General Hospital, Athens, Greece.
⁴ First Department of Pathology, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece.
⁵ Co-senior authors.

Abstract

Surface bone sarcomas are rare malignant bone tumours. Osseous and cartilaginous surface bone sarcomas are the most common, with parosteal and periosteal osteosarcomas, periosteal chondrosarcomas and secondary peripheral chondrosarcomas being the most frequent.Their clinical symptoms are non-specific and include pain for several months, swelling and limited range of motion of the adjacent joints.Prompt diagnosis is important, as biological behaviour, imaging and histopathologic characteristics, treatment and prognosis differ considerably from their conventional intramedullary counterparts. Moreover, their imaging characteristics are not infrequently non-characteristic and may be misinterpreted as juxtacortical benign lesions leading to incorrect diagnosis and treatment, with life-threatening repercussions. Molecular studies and histopathological sampling are essential for accurate diagnosis.There are still numerous issues regarding the biology, pathophysiology and treatment options of these entities due to their rarity. Cite this article: EFORT Open Rev 2021;6:905-917. DOI: 10.1302/2058-5241.6.210064.

Keywords: juxtacortical tumours; surface bone tumours.

Publication types

Review