Spiking immunotherapy with a bacterial cocktail brings T cells back to the fight

K Leigh Greathouse; Ankan Choudhury

doi:10.1016/j.xcrm.2021.100430

Spiking immunotherapy with a bacterial cocktail brings T cells back to the fight

Cell Rep Med. 2021 Oct 19;2(10):100430. doi: 10.1016/j.xcrm.2021.100430.

Authors

K Leigh Greathouse^{1

2}, Ankan Choudhury²

Affiliations

¹ Nutrition Sciences, Robbins College of Health and Human Sciences, Baylor University, Waco, TX, USA.
² Department of Biology, College of Arts and Sciences, Baylor University, Waco, TX, USA.

Abstract

A recent study by Montalban-Arques et al.¹ in Cell Host & Microbe shows that augmenting the function of the gut microbiota reduces tumor burden. Four Clostridiales species blocked tumor growth as efficient as chemotherapy or immunotherapy in colorectal cancer and melanoma.

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MeSH terms

Bacteria
Gastrointestinal Microbiome*
Humans
Immunotherapy
Melanoma* / therapy
T-Lymphocytes