Recent Updates of Natural and Synthetic URAT1 Inhibitors and Novel Screening Methods

Ying Chen; Ruya You; Ke Wang; Yousheng Wang

doi:10.1155/2021/5738900

Recent Updates of Natural and Synthetic URAT1 Inhibitors and Novel Screening Methods

Evid Based Complement Alternat Med. 2021 Oct 31:2021:5738900. doi: 10.1155/2021/5738900. eCollection 2021.

Authors

Ying Chen^{1

2

3}, Ruya You^{1

2

3}, Ke Wang^{1

2

3}, Yousheng Wang^{1

2

3}

Affiliations

¹ Beijing Advanced Innovation Centre for Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), Beijing, China.
² Rizhao HUAWEI Institute of Comprehensive Health Industries, Rizhao, Shandong, China.
³ Shandong KEEPFIT Biotech. Co., Ltd., Rizhao, Shandong, China.

Abstract

Human urate anion transporter 1 (hURAT1) is responsible for the reabsorption of uric acid in the proximal renal tubules and is a promising therapeutic target for treating hyperuricemia. To mitigate the side effects of URAT1-targeted clinical agents such as benzbromarone, there is significant interest in discovering new URAT1 inhibitors and developing technology that can evaluate URAT1 inhibition. This review summarizes the methods for assay of URAT1 inhibition and the progress on the discovery of natural and synthetic URAT1 inhibitors in the past five years.

Publication types

Review