Kinetics and mechanistic investigations on antiviral drug-valacyclovir hydrochloride by heptavalent alkaline permanganate

Suresh M Tuwar; Rohini M Hanabaratti

doi:10.1007/s12039-021-01969-4

Kinetics and mechanistic investigations on antiviral drug-valacyclovir hydrochloride by heptavalent alkaline permanganate

J Chem Sci (Bangalore). 2021;133(4):114. doi: 10.1007/s12039-021-01969-4. Epub 2021 Nov 3.

Authors

Suresh M Tuwar¹, Rohini M Hanabaratti¹

Affiliation

¹ Department of Chemistry, Karnatak Science College, Dharwad, Karnataka 580 001 India.

Abstract

Abstract: Kinetics of Permanganate (MnO₄ ^-) oxidation of antiviral drug, valacyclovir hydrochloride (VCH) has been studied spectrophotometrically at a constant ionic strength of 0.1 mol dm^-3. The reaction exhibiting a 2:1 stoichiometry (MnO₄ ^-:VCH) has been studied over a wide range of experimental conditions. It was found that the rate enhancement was associated with an increase in concentrations of alkali, reductant and temperature. A plausible mechanism involving an intermediate Mn(VII)-VCH complex (C) was expected and rate law is derived accordingly. Calculated activation parameters also supported the anticipated mechanism.

Supplementary information: The online version contains supplementary material available at 10.1007/s12039-021-01969-4.

Keywords: Heptavalent permanganate; Identification of product; Kinetics; Mechanism; Oxidation; Valacyclovir hydrochloride.