Pathophysiology of Obesity

Abstract

As obesity continues a relentless march across the globe, researchers are beginning to unlock the complicated interplay among obesity, its ensuing inflammation, and downstream complications. It is becoming clear that obesity is a chronic, multifactorial, inflammatory disease of maladaptive adipose tissue mass involving complex links among genetics, hormonal-signaling, and the environment. Understanding the intricate pathogenesis of obesity and its sequela will go a long way to discovering better treatment options and lessen anti-obesity bias.

Keywords: Adipokines; Adipose tissue; Appetite regulation; Chronotype; Energy balance; Epigenetics; Metabolic adaptation; Obesity.